One Step Beyond episode "Vanishing Point" which originally aired on February 23, 1960

Thanks to Dean Rose who recently watched this episode and sent us the screen grabs.
The story deals with a man whose wife mysteriously vanishes from the house. He later discovered that two other people have vanished including the builder of the house. Newland remarks that before Einstein we believed in only three dimensions and now we know there to be four. Perhaps the people who vanished have discovered a fifth dimension.

Or, perhaps, George set up a temporal rift in the house and people are disappearing in time...